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KMID : 0043320110340101593
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Archives of Pharmacal Research
2011 Volume.34 No. 10 p.1593 ~ p.1598
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Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum
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Nhiem Nguyen Xuan
Kiem Phan Van
Minh Chau Van
Tai Bui Huu
Quang Tran Hong
Soung Kwang-Su
Koo Jung-Eun
Koh Young-Sang
Kim Young-Ho
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Abstract
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Acanthopanax koreanum is well known herb in traditional Korean, Chinese, and Japanese anti-inflammatory action without any adverse effects. In the current study, we investigated the inhibitory effects of isolated compounds 1?13 from the leaves of A. koreanum on the lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrowderived dendritic cells. Of these lupane-type triterpenoids, 1 exhibited particularly high inhibitory effect on lipopolysaccharide-stimulated TNF-α, IL-6, and IL-12 production with the values ranging from 45.0 to 84.5% at a concentration of 50 μM. These results warrant further studies concerning the potential anti-inflammatory benefits of medicinal foods containing the leaves of A. koreanum.
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KEYWORD
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Acanthopanax koreanum, Araliaceae, Lupane-triterpenoids, TNF-α, IL-6, IL-12, LPS-stimulated pro-inflammatory cytokine
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